#05 Evaluation of chemical-specific IgG antibodies in male workers from a urethane foam factory
What is it about?
Plastic resins are complex chemicals. The several chemicals cause occupational allergies (OA), including respiratory allergies. However, when a suspected OA patient occurs in a factory, we tend to investigate only the most famous causative chemicals as the causative substances of OA. Is that really enough?
We investigated the chemicals that might be contained in urethane resin in a factory and looked for chemicals that could cause occupational asthma. Finally, we narrowed down the two potential chemicals, toluene diisocyanate (TDI) and trimellitic anhydride (TMA), to check if the two suspected OA patients had chemical-specific antibodies.
The results showed that two suspected OA patients had both TDI and TMA-specific antibodies.
Why is it important?
TDI, a polymer of polyurethane resin is a very famous cause of OA. The details of what chemicals are contained in plastic resin are corporate secrets. Therefore, it is necessary to carefully investigate what kind of chemical substances are contained in addition to the polymer.
Perspectives
Workers will often be exposed to multiple chemicals at the same time, not only in plastic resin factories but also in various factories. It is important for us to maintain a combined exposure perspective whenever we seek the cause of allergic disease in the workplace.
Link to the original journal article: https://environhealthprevmed.biomedcentral.com/articles/10.1186/s12199-018-0713-4
Title of this article: Evaluation of chemical-specific IgG antibodies in male workers from a urethane foam factory
Authors: Mayumi Tsuji, Yasuhiro Ishihara, Toyohi Isse, Chihaya Koriyama, Megumi Yamamoto, Noriaki Kakiuchi, Hsu-Sheng Yu, Masayuki Tanaka, Takuto Tsuchiya, Masanori Ohta, Rie Tanaka, Toshihiro Kawamoto
This article is an open access article under the terms of the Creative Commons Attribution- NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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